A database of hormones and their receptors |
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HMRbase accession number | 21074 |
Swiss-prot Accession number | Q16671 (Sequence in FASTA format) |
Description | Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30)(Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIStype II receptor) (MISRII) (MRII). |
Source organism | Homo sapiens (Human) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
Subcellular location | Membrane; single-pass type I membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. |
Protein Length | 573 Amino acids |
Molecular weight | 62750 |
Domain Name | Pkinase Pkinase_Tyr |
References | 1 PubMed abstract 7493017 2 PubMed abstract 7488027 3 PubMed abstract 10589763 4 PubMed abstract 15489334 5 PubMed abstract 8872466 6 PubMed abstract 11549681 |
Hormone | P03971 Detail in HMRbase |
Gene ID | 269 |
PDB ID | N/A |
Drugpedia | wiki |
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