A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21071 |
| Swiss-prot Accession number | Q03431 (Sequence in FASTA format) |
| Description | Parathyroid hormone/parathyroid hormone-related peptide receptorprecursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Expressed in most tissues. Most abundant in kidney, bone and liver. |
| Post translational modification | N/A |
| Function | This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 593 Amino acids |
| Molecular weight | 66361 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 8386612 2 PubMed abstract 8397094 3 PubMed abstract 7745008 4 Levine M.A.; "Characterization of cDNA and genomic DNA encoding the human PTH/PTHrPreceptor."; Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases. 5 King M.M., Aronstam R.S., Sharma S.V.; "Isolation of cDNA coding for parathyroid hormone receptor 1(PTHR1)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15489334 7 PubMed abstract 10913300 8 PubMed abstract 9737850 9 PubMed abstract 7701349 10 PubMed abstract 8703170 11 PubMed abstract 9178745 12 PubMed abstract 9745456 13 PubMed abstract 10487664 14 PubMed abstract 11850620 15 PubMed abstract 15523647 16 PubMed abstract 8386612 17 PubMed abstract 8397094 18 PubMed abstract 7745008 19 Levine M.A.; "Characterization of cDNA and genomic DNA encoding the human PTH/PTHrPreceptor."; Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases. 20 King M.M., Aronstam R.S., Sharma S.V.; "Isolation of cDNA coding for parathyroid hormone receptor 1(PTHR1)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 21 PubMed abstract 15489334 22 PubMed abstract 10913300 23 PubMed abstract 9737850 24 PubMed abstract 7701349 25 PubMed abstract 8703170 26 PubMed abstract 9178745 27 PubMed abstract 9745456 28 PubMed abstract 10487664 29 PubMed abstract 11850620 30 PubMed abstract 15523647 |
| Hormone | P01270 Detail in HMRbase |
| Gene ID | 5745 |
| PDB ID | 1BL1 1ET2 1ET3 3C4M |
| Drugpedia | wiki |
| Comments |