A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21069 |
| Swiss-prot Accession number | Q02643 (Sequence in FASTA format) |
| Description | Growth hormone-releasing hormone receptor precursor (GHRH receptor)(GRF receptor) (GRFR). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Pituitary gland. |
| Post translational modification | N/A |
| Function | Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. |
| Protein Length | 423 Amino acids |
| Molecular weight | 47402 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 1333056 2 PubMed abstract 7680413 3 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 4 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 12853948 6 Tang J., Collu R.; "The structure of the gene coding for human growth hormone releasinghormone."; Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 11232012 8 PubMed abstract 10084571 9 PubMed abstract 12534354 |
| Hormone | P01286 Detail in HMRbase Q9UBU3 Detail in HMRbase |
| Gene ID | 2692 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |