A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21065 |
| Swiss-prot Accession number | Q01726 (Sequence in FASTA format) |
| Description | Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropinreceptor) (Melanocortin receptor 1) (MC1-R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Melanocytes and corticoadrenal tissue. |
| Post translational modification | N/A |
| Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. |
| Protein Length | 317 Amino acids |
| Molecular weight | 34706 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1325670 2 PubMed abstract 8463333 3 PubMed abstract 1516719 4 PubMed abstract 8706868 5 PubMed abstract 10101176 6 PubMed abstract 11442765 7 Smith A.G., Box N.F., Marks L., Chen W., Sturm R.A.; "Complete sequence and characterization of the human melanocortin 1receptor locus: a study of promoter region polymorphism."; Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. 8 PubMed abstract 11707265 9 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 10 Rieder M.J., Armel T.Z., Carrington D.P., Ozuna M., Kuldanek S.A.,Toth E.J., Yi Q., Nickerson D.A.; "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases. 11 PubMed abstract 15489334 12 PubMed abstract 9640562 13 PubMed abstract 7581459 14 PubMed abstract 8894704 15 PubMed abstract 9302268 16 PubMed abstract 8990005 17 PubMed abstract 9571181 18 PubMed abstract 9665397 19 PubMed abstract 1325670 20 PubMed abstract 8463333 21 PubMed abstract 1516719 22 PubMed abstract 8706868 23 PubMed abstract 10101176 24 PubMed abstract 11442765 25 Smith A.G., Box N.F., Marks L., Chen W., Sturm R.A.; "Complete sequence and characterization of the human melanocortin 1receptor locus: a study of promoter region polymorphism."; Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases. 26 PubMed abstract 11707265 27 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 28 Rieder M.J., Armel T.Z., Carrington D.P., Ozuna M., Kuldanek S.A.,Toth E.J., Yi Q., Nickerson D.A.; "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases. 29 PubMed abstract 15489334 30 PubMed abstract 9640562 31 PubMed abstract 7581459 32 PubMed abstract 8894704 33 PubMed abstract 9302268 34 PubMed abstract 8990005 35 PubMed abstract 9571181 36 PubMed abstract 9665397 |
| Hormone | P01189 Detail in HMRbase |
| Gene ID | 4157 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |