A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21064 |
| Swiss-prot Accession number | Q01718 (Sequence in FASTA format) |
| Description | Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R)(Melanocortin receptor 2) (MC2-R) (Adrenocorticotropin receptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Melanocytes and corticoadrenal tissue. |
| Post translational modification | N/A |
| Function | Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. |
| Protein Length | 297 Amino acids |
| Molecular weight | 33927 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1325670 2 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 3 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 15489334 5 PubMed abstract 8463333 6 PubMed abstract 15654338 7 Clark A.J.L., Weber A.; "Molecular insights into inherited ACTH resistance syndromes."; Trends Endocrinol. Metab. 5:209-214(1994). 8 PubMed abstract 8094489 9 PubMed abstract 8227361 10 PubMed abstract 8636348 11 PubMed abstract 10971458 12 PubMed abstract 12213892 13 PubMed abstract 1325670 14 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 15 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 16 PubMed abstract 15489334 17 PubMed abstract 8463333 18 PubMed abstract 15654338 19 Clark A.J.L., Weber A.; "Molecular insights into inherited ACTH resistance syndromes."; Trends Endocrinol. Metab. 5:209-214(1994). 20 PubMed abstract 8094489 21 PubMed abstract 8227361 22 PubMed abstract 8636348 23 PubMed abstract 10971458 24 PubMed abstract 12213892 25 PubMed abstract 1325670 26 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 27 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 28 PubMed abstract 15489334 29 PubMed abstract 8463333 30 PubMed abstract 15654338 31 Clark A.J.L., Weber A.; "Molecular insights into inherited ACTH resistance syndromes."; Trends Endocrinol. Metab. 5:209-214(1994). 32 PubMed abstract 8094489 33 PubMed abstract 8227361 34 PubMed abstract 8636348 35 PubMed abstract 10971458 36 PubMed abstract 12213892 |
| Hormone | P01189 Detail in HMRbase |
| Gene ID | 4158 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |