A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21057 |
| Swiss-prot Accession number | P56495 (Sequence in FASTA format) |
| Description | Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor). |
| Source organism | Ovis aries (Sheep) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 6 LRR (leucine-rich) repeats. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). |
| Protein Length | 764 Amino acids |
| Molecular weight | 86674 |
| Domain Name | 7tm_1 LRR_1 |
| References | 1 PubMed abstract 9299474 |
| Hormone | P01218 Detail in HMRbase |
| Gene ID | 443428 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |