A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21056 |
| Swiss-prot Accession number | P56481 (Sequence in FASTA format) |
| Description | Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR)(Cholecystokinin-2 receptor) (CCK2-R). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). |
| Protein Length | 453 Amino acids |
| Molecular weight | 49172 |
| Domain Name | 7tm_1 |
| References | 1 Kopin A.S.; Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 10860839 3 PubMed abstract 16141072 4 Kopin A.S.; Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 10860839 6 PubMed abstract 16141072 |
| Hormone | P09240 Detail in HMRbase P48757 Detail in HMRbase |
| Gene ID | 12426 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |