| HMRbase accession number | 21047 |
| Swiss-prot Accession number | P47866 (Sequence in FASTA format) |
| Description | Corticotropin-releasing factor receptor 2 precursor (CRF-R 2) (CRF2)(Corticotropin-releasing hormone receptor 2) (CRH-R 2). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Predominantly expressed in limbic regions of the brain such as the lateral septum, the entorhinal cortex, the hypothalamic ventromedial nucleus and several amygdaloid nuclei. Also detectable in lung, kidney and heart. |
| Post translational modification | N/A |
| Function | This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
| Protein Length | 411 Amino acids |
| Molecular weight | 47707 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 7846062
2 Lovenberg T.W., Liaw C.W., Grigoriadis D.E., Clevenger W.,Chalmers D.T., de Souza E.B., Oltersdorf T.; Proc. Natl. Acad. Sci. U.S.A. 92:5759-5759(1995).
|
| Hormone | P01143 Detail in HMRbase
|
| Gene ID | 64680 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors