A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21032 |
| Swiss-prot Accession number | P34993 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 2 (SS2R) (SRIF-1). |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. |
| Protein Length | 368 Amino acids |
| Molecular weight | 41134 |
| Domain Name | 7tm_1 |
| References | 1 Xin W.W., Wong M.-L., Rimland J., Nestler E.J., Duman R.S.; "Characterization and functional expression of a somatostatin receptorisolated from locus Coeruleus."; Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
2 Xin W.W., Wong M.-L., Rimland J., Nestler E.J., Duman R.S.; "Characterization and functional expression of a somatostatin receptorisolated from locus Coeruleus."; Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases. |
| Hormone | P26917 Detail in HMRbase |
| Gene ID | 282083 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |