A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21029 |
| Swiss-prot Accession number | P32745 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 3 (SS3R) (SSR-28). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein (By similarity). Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Brain, pituitary and pancreas. |
| Post translational modification | Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity). |
| Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. |
| Protein Length | 418 Amino acids |
| Molecular weight | 45847 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1337145 2 PubMed abstract 8097479 3 Rasch A.C., Boehnke C., Petersenn S.; "The human somatostatin receptor subtype 3 contains an upstream exonin the 5'-untranslated region: functional promoter studies."; Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. 4 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15461802 6 PubMed abstract 10591208 7 PubMed abstract 15489334 8 PubMed abstract 1337145 9 PubMed abstract 8097479 10 Rasch A.C., Boehnke C., Petersenn S.; "The human somatostatin receptor subtype 3 contains an upstream exonin the 5'-untranslated region: functional promoter studies."; Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. 11 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 12 PubMed abstract 15461802 13 PubMed abstract 10591208 14 PubMed abstract 15489334 15 PubMed abstract 1337145 16 PubMed abstract 8097479 17 Rasch A.C., Boehnke C., Petersenn S.; "The human somatostatin receptor subtype 3 contains an upstream exonin the 5'-untranslated region: functional promoter studies."; Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. 18 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 19 PubMed abstract 15461802 20 PubMed abstract 10591208 21 PubMed abstract 15489334 |
| Hormone | P61278 Detail in HMRbase |
| Gene ID | 6753 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |