A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21021 |
| Swiss-prot Accession number | P31391 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 4 (SS4R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals. |
| Post translational modification | N/A |
| Function | Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. |
| Protein Length | 388 Amino acids |
| Molecular weight | 41895 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8512564 2 PubMed abstract 8483934 3 PubMed abstract 8373420 4 PubMed abstract 8100352 5 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 11780052 7 PubMed abstract 15489334 8 PubMed abstract 8512564 9 PubMed abstract 8483934 10 PubMed abstract 8373420 11 PubMed abstract 8100352 12 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. 13 PubMed abstract 11780052 14 PubMed abstract 15489334 |
| Hormone | P61278 Detail in HMRbase |
| Gene ID | 6754 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |