A database of hormones and their receptors
Receptor

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HMRbase accession number21021
Swiss-prot Accession numberP31391 (Sequence in FASTA format)
DescriptionSomatostatin receptor type 4 (SS4R).
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationCell membrane; multi-pass membrane protein
Developmental StageN/A
Similarity Belongs to the G-protein coupled receptor 1 family.
Tissue SpecificitySpecifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
Post translational modificationN/A
Function Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
Protein Length388 Amino acids
Molecular weight41895
Domain Name7tm_1  
References1  PubMed abstract 8512564
2  PubMed abstract 8483934
3  PubMed abstract 8373420
4  PubMed abstract 8100352
5   Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
6  PubMed abstract 11780052
7  PubMed abstract 15489334
8  PubMed abstract 8512564
9  PubMed abstract 8483934
10  PubMed abstract 8373420
11  PubMed abstract 8100352
12   Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
13  PubMed abstract 11780052
14  PubMed abstract 15489334
HormoneP61278   Detail in HMRbase   
Gene ID6754      
PDB IDN/A
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