A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21020 |
| Swiss-prot Accession number | P30988 (Sequence in FASTA format) |
| Description | Calcitonin receptor precursor (CT-R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. |
| Protein Length | 490 Amino acids |
| Molecular weight | 57303 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 1331173 2 PubMed abstract 8078488 3 PubMed abstract 7588285 4 PubMed abstract 8143880 5 PubMed abstract 10570950 6 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 12853948 8 PubMed abstract 15489334 9 PubMed abstract 15340161 10 PubMed abstract 7720653 11 PubMed abstract 7733946 12 PubMed abstract 15086532 13 PubMed abstract 9817931 14 PubMed abstract 1331173 15 PubMed abstract 8078488 16 PubMed abstract 7588285 17 PubMed abstract 8143880 18 PubMed abstract 10570950 19 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 20 PubMed abstract 12853948 21 PubMed abstract 15489334 22 PubMed abstract 15340161 23 PubMed abstract 7720653 24 PubMed abstract 7733946 25 PubMed abstract 15086532 26 PubMed abstract 9817931 |
| Hormone | P01258 Detail in HMRbase |
| Gene ID | 799 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |