A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21018 |
| Swiss-prot Accession number | P30968 (Sequence in FASTA format) |
| Description | Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Pituitary, ovary, testis, breast and prostate but not in liver and spleen. |
| Post translational modification | N/A |
| Function | Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act a an inhibitor of GnRH-R signaling. |
| Protein Length | 328 Amino acids |
| Molecular weight | 37731 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1333190 2 PubMed abstract 8386108 3 PubMed abstract 7534732 4 PubMed abstract 9272108 5 PubMed abstract 9259321 6 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 15489334 8 PubMed abstract 10366411 9 PubMed abstract 9371856 10 PubMed abstract 9425890 11 PubMed abstract 10022417 12 PubMed abstract 10084584 13 PubMed abstract 10523035 14 PubMed abstract 11397842 15 PubMed abstract 11318785 16 PubMed abstract 11397871 17 PubMed abstract 11994356 18 PubMed abstract 12679486 |
| Hormone | O43555 Detail in HMRbase P01148 Detail in HMRbase Q6X4W1 Detail in HMRbase |
| Gene ID | 2798 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |