A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21013 |
| Swiss-prot Accession number | P30875 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 2 (SS2R) (SRIF-1). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Cerebrum and kidney. |
| Post translational modification | N/A |
| Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. |
| Protein Length | 369 Amino acids |
| Molecular weight | 41222 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1346068 2 PubMed abstract 1397330 3 PubMed abstract 11278805 4 PubMed abstract 7913111 5 PubMed abstract 8104154 6 PubMed abstract 1346068 7 PubMed abstract 1397330 8 PubMed abstract 11278805 9 PubMed abstract 7913111 10 PubMed abstract 8104154 |
| Hormone | P60041 Detail in HMRbase |
| Gene ID | 20606 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |