A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20996 |
| Swiss-prot Accession number | P22888 (Sequence in FASTA format) |
| Description | Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) (LSH-R) (Luteinizing hormone receptor) (LHR). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 7 LRR (leucine-rich) repeats. |
| Tissue Specificity | Gonadal and thyroid cells. |
| Post translational modification | N/A |
| Function | Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. |
| Protein Length | 699 Amino acids |
| Molecular weight | 78616 |
| Domain Name | 7tm_1 LRR_1 |
| References | 1 PubMed abstract 2244890 2 PubMed abstract 1922095 3 PubMed abstract 2293030 4 PubMed abstract 7556872 5 PubMed abstract 9858858 6 PubMed abstract 8747461 7 PubMed abstract 15539429 8 PubMed abstract 7692306 9 PubMed abstract 8281137 10 PubMed abstract 7757065 11 PubMed abstract 7714085 12 PubMed abstract 7629248 13 PubMed abstract 7719343 14 PubMed abstract 8829636 15 PubMed abstract 8929952 16 PubMed abstract 8559204 17 PubMed abstract 9215288 18 PubMed abstract 10215412 19 PubMed abstract 9467560 20 PubMed abstract 9626144 21 PubMed abstract 9661624 22 PubMed abstract 9851790 23 PubMed abstract 9514160 24 PubMed abstract 9626653 25 PubMed abstract 10580072 |
| Hormone | P01215 Detail in HMRbase P01229 Detail in HMRbase |
| Gene ID | 3973 |
| PDB ID | 1LUT 1XUL |
| Drugpedia | wiki |
| Comments |