A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20987 |
| Swiss-prot Accession number | P16473 (Sequence in FASTA format) |
| Description | Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 6 LRR (leucine-rich) repeats. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). |
| Protein Length | 764 Amino acids |
| Molecular weight | 86830 |
| Domain Name | 7tm_1 LRR_1 |
| References | 1 PubMed abstract 2558651 2 PubMed abstract 2610690 3 PubMed abstract 2302212 4 PubMed abstract 2293030 5 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 1530609 7 PubMed abstract 11502179 8 PubMed abstract 12045258 9 PubMed abstract 8747461 10 PubMed abstract 11887032 11 PubMed abstract 12593721 12 PubMed abstract 12930595 13 PubMed abstract 10870027 14 PubMed abstract 1955520 15 PubMed abstract 8413627 16 PubMed abstract 7508946 17 PubMed abstract 8045989 18 PubMed abstract 7989485 19 PubMed abstract 7920658 20 PubMed abstract 7556878 21 PubMed abstract 7800007 22 PubMed abstract 7528344 23 PubMed abstract 7647578 24 PubMed abstract 7488864 25 PubMed abstract 8636266 26 PubMed abstract 8964822 27 PubMed abstract 8954020 28 PubMed abstract 9062474 29 PubMed abstract 9100579 30 PubMed abstract 9253356 31 PubMed abstract 9329388 32 PubMed abstract 9360555 33 PubMed abstract 9398746 34 PubMed abstract 9185526 35 PubMed abstract 9294132 36 PubMed abstract 9349581 37 PubMed abstract 9589634 38 PubMed abstract 9854118 39 PubMed abstract 10199795 40 PubMed abstract 10487707 41 PubMed abstract 10037070 42 PubMed abstract 10560955 43 PubMed abstract 11022192 44 PubMed abstract 10651846 45 PubMed abstract 10720030 46 PubMed abstract 10852462 47 PubMed abstract 10946859 48 PubMed abstract 11095460 49 PubMed abstract 11127522 50 PubMed abstract 11081252 51 PubMed abstract 11128715 52 PubMed abstract 11201847 53 PubMed abstract 11517004 54 PubMed abstract 11549687 55 PubMed abstract 11434721 56 PubMed abstract 11442002 57 PubMed abstract 12213664 58 PubMed abstract 12050212 59 PubMed abstract 12589819 60 PubMed abstract 12788902 61 PubMed abstract 14759073 62 PubMed abstract 14725684 63 PubMed abstract 15163335 64 PubMed abstract 15531543 |
| Hormone | P01215 Detail in HMRbase P01222 Detail in HMRbase Q86YW7 Detail in HMRbase Q96T91 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | 1XUM |
| Drugpedia | wiki |
| Comments |