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HMRbase accession number | 20951 |
Swiss-prot Accession number | P79222 (Sequence in FASTA format) |
Description | Calcitonin receptor precursor (CT-R). |
Source organism | Oryctolagus cuniculus (Rabbit) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;Oryctolagus. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 2 family. |
Tissue Specificity | Isoform 1 and isoform 2 are expressed in a tissue-specific manner, with isoform 2 accounting for less than 15% of the total calcitonin receptor mRNA in osteoclasts, kidney, and brain, but comprising at least 50% of the transcripts in skeletal muscle and lung. |
Post translational modification | N/A |
Function | This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Isoform 2 has altered ligand binding and abolished coupling to phospholipase C. |
Protein Length | 474 Amino acids |
Molecular weight | 55235 |
Domain Name | 7tm_2 HRM |
References | 1 PubMed abstract 8940110 2 PubMed abstract 8940110 |
Hormone | N/A |
Gene ID | 100009231 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |