A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20860 |
| Swiss-prot Accession number | P30560 (Sequence in FASTA format) |
| Description | Vasopressin V1a receptor (V1aR) (Vascular/hepatic-type argininevasopressin receptor) (Antidiuretic hormone receptor 1a) (AVPR V1a). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein. Cytoplasmic vesicle; cytoplasmic vesicle membrane; multi-pass membrane protein. Note=Located in cytoplasmic vesicles dispersed throughout the cell cytoplasm and to the plasma membrane |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Localized within gonadotropes of the anterior pituitary of the brain. Broadly distributed throughout the cerebral cortex. |
| Post translational modification | Palmitoylated on three cysteine residues, of which only two are identified. |
| Function | Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation. |
| Protein Length | 424 Amino acids |
| Molecular weight | 47655 |
| Domain Name | 7tm_1 DUF1856 |
| References | 1 PubMed abstract 1560825 2 PubMed abstract 8257445 3 PubMed abstract 8670090 4 PubMed abstract 15489334 5 PubMed abstract 8511367 6 PubMed abstract 7774575 7 PubMed abstract 9105680 8 PubMed abstract 11520055 9 PubMed abstract 11466323 10 PubMed abstract 12399435 11 PubMed abstract 12887422 12 PubMed abstract 1560825 13 PubMed abstract 8257445 14 PubMed abstract 8670090 15 PubMed abstract 15489334 16 PubMed abstract 8511367 17 PubMed abstract 7774575 18 PubMed abstract 9105680 19 PubMed abstract 11520055 20 PubMed abstract 11466323 21 PubMed abstract 12399435 22 PubMed abstract 12887422 23 PubMed abstract 1560825 24 PubMed abstract 8257445 25 PubMed abstract 8670090 26 PubMed abstract 15489334 27 PubMed abstract 8511367 28 PubMed abstract 7774575 29 PubMed abstract 9105680 30 PubMed abstract 11520055 31 PubMed abstract 11466323 32 PubMed abstract 12399435 33 PubMed abstract 12887422 |
| Hormone | N/A |
| Gene ID | 25107 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |