A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20801 |
| Swiss-prot Accession number | P13945 (Sequence in FASTA format) |
| Description | Beta-3 adrenergic receptor (Beta-3 adrenoceptor) (Beta-3adrenoreceptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed mainly in adipose tissues. |
| Post translational modification | N/A |
| Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. |
| Protein Length | 408 Amino acids |
| Molecular weight | 43519 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 2570461 2 PubMed abstract 8389293 3 PubMed abstract 8389717 4 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases. 5 Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O.,Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.; "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15489334 7 PubMed abstract 1336117 8 PubMed abstract 7609752 9 PubMed abstract 8721782 10 PubMed abstract 8641219 11 PubMed abstract 10391210 |
| Hormone | Detail in HMRbase |
| Gene ID | 155 |
| PDB ID | 2CDW |
| Drugpedia | wiki |
| Comments |