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HMRbase accession number | 20794 |
Swiss-prot Accession number | Q8UUY8 (Sequence in FASTA format) |
Description | Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). |
Source organism | Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei;Protacanthopterygii; Salmoniformes; Salmonidae; Oncorhynchus. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | Highly expressed in the liver and red and white muscle, with lower levels of expression in the gills, heart, kidney and spleen. |
Post translational modification | Lacks the regulatory protein kinase A phosphorylation sites within the G-protein binding domain that mediate desensitization and are present in mammalian homologs. |
Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity). |
Protein Length | 409 Amino acids |
Molecular weight | 45098 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 11737201 |
Hormone | N/A |
Gene ID | 100136153 |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Hormone for this Receptor are either unknown or have not yet been curated |