A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20790 |
| Swiss-prot Accession number | P07550 (Sequence in FASTA format) |
| Description | Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | Palmitoylated; may reduce accessibility of Ser-345 and Ser- 346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA- mediated phosphorylation seems to facilitate phosphorylation by BARK. |
| Function | Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. |
| Protein Length | 413 Amino acids |
| Molecular weight | 46557 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 3033609 2 PubMed abstract 3025863 3 PubMed abstract 3026848 4 PubMed abstract 2823249 5 PubMed abstract 3034889 6 Rupert J.R., Hochachka P.W.; "Beta-2-adrenergic receptor allele frequencies in two native Americanpopulations."; Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases. 7 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. 8 Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O.,Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.; "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases. 9 PubMed abstract 2831218 10 PubMed abstract 2540197 11 PubMed abstract 11146000 12 PubMed abstract 10499588 13 PubMed abstract 12142540 14 PubMed abstract 8383511 15 PubMed abstract 7915137 16 PubMed abstract 7706471 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 154 |
| PDB ID | 2R4R 2R4S 3D4S |
| Drugpedia | wiki |
| Comments |