A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20771 |
| Swiss-prot Accession number | P18825 (Sequence in FASTA format) |
| Description | Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2Cadrenoreceptor) (Alpha-2 adrenergic receptor subtype C4). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. |
| Protein Length | 462 Amino acids |
| Molecular weight | 49522 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 2842764 2 PubMed abstract 9371698 3 Yano K., Takeda M., Sugimoto E., Sagai H.; "Molecular cloning and expression of a novel human alpha2C-adrenergincreceptor, alpha2CII, gene."; Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 10801795 5 PubMed abstract 15319474 6 Kopatz S.A., Aronstam R.S., Sharma S.V.; "Isolation of complete coding sequence for adrenergic receptor alpha2C (ADRA2C)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 1849485 |
| Hormone | Detail in HMRbase |
| Gene ID | 152 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |