A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20761 |
| Swiss-prot Accession number | P08913 (Sequence in FASTA format) |
| Description | Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. |
| Protein Length | 450 Amino acids |
| Molecular weight | 48957 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 2568356 2 PubMed abstract 2823383 3 PubMed abstract 2170371 4 PubMed abstract 10948191 5 PubMed abstract 16567612 6 Mao Z.-M., Tang K., Li B.-M., Jing N.-H.; "Cloning and expression of human alpha-2A adrenergic receptor in SY5Ycells."; Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. 7 Castellano M., Giacche' M., Rossi F., Rivadossi F., Perani C.,Beschi M., Agabiti Rosei E.; "A search for genetic variability in the human alpha-2 adrenergicreceptor on chromosome 10."; Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. 8 Liu L., Yuan L.; "Human alpha-2A adrenergic receptor gene and the genotype of -1296nucleotide and motionsickness."; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. 9 Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O.,Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.; "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases. 10 PubMed abstract 15164054 11 PubMed abstract 15489334 12 PubMed abstract 1849485 13 PubMed abstract 1678390 14 PubMed abstract 1678850 15 PubMed abstract 17081983 16 PubMed abstract 11888275 17 PubMed abstract 2568356 18 PubMed abstract 2823383 19 PubMed abstract 2170371 20 PubMed abstract 10948191 21 PubMed abstract 16567612 22 Mao Z.-M., Tang K., Li B.-M., Jing N.-H.; "Cloning and expression of human alpha-2A adrenergic receptor in SY5Ycells."; Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. 23 Castellano M., Giacche' M., Rossi F., Rivadossi F., Perani C.,Beschi M., Agabiti Rosei E.; "A search for genetic variability in the human alpha-2 adrenergicreceptor on chromosome 10."; Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. 24 Liu L., Yuan L.; "Human alpha-2A adrenergic receptor gene and the genotype of -1296nucleotide and motionsickness."; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. 25 Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O.,Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.; "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases. 26 PubMed abstract 15164054 27 PubMed abstract 15489334 28 PubMed abstract 1849485 29 PubMed abstract 1678390 30 PubMed abstract 1678850 31 PubMed abstract 17081983 32 PubMed abstract 11888275 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 150 |
| PDB ID | 1HLL 1HO9 1HOD 1HOF |
| Drugpedia | wiki |
| Comments |