A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20746 |
| Swiss-prot Accession number | P35348 (Sequence in FASTA format) |
| Description | Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A-adrenoreceptor) (Alpha-1C adrenergic receptor) (Alpha adrenergicreceptor 1c). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. |
| Post translational modification | Carboxyl-terminal Ser or Thr residues may be phosphorylated (By similarity). |
| Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. |
| Protein Length | 466 Amino acids |
| Molecular weight | 51487 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8396931 2 PubMed abstract 8024574 3 PubMed abstract 8183249 4 PubMed abstract 8564208 5 PubMed abstract 7815325 6 PubMed abstract 7737411 7 PubMed abstract 9490024 8 PubMed abstract 10493934 9 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 10 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. 11 PubMed abstract 8832064 12 PubMed abstract 15179408 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 148 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |