A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20713 |
| Swiss-prot Accession number | P43220 (Sequence in FASTA format) |
| Description | Glucagon-like peptide 1 receptor precursor (GLP-1 receptor) (GLP-1-R)(GLP-1R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
| Protein Length | 463 Amino acids |
| Molecular weight | 53060 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 8405712 2 PubMed abstract 8404634 3 PubMed abstract 8216285 4 PubMed abstract 7517895 5 PubMed abstract 7843404 6 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 7 Rieder M.J., Livingston R.J., Daniels M.R., Montoya M.A., Chung M.-W.,Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D.,Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 8 PubMed abstract 14574404 9 PubMed abstract 15489334 10 PubMed abstract 9213353 11 PubMed abstract 8405712 12 PubMed abstract 8404634 13 PubMed abstract 8216285 14 PubMed abstract 7517895 15 PubMed abstract 7843404 16 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 17 Rieder M.J., Livingston R.J., Daniels M.R., Montoya M.A., Chung M.-W.,Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D.,Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 18 PubMed abstract 14574404 19 PubMed abstract 15489334 20 PubMed abstract 9213353 |
| Hormone | N/A |
| Gene ID | 2740 |
| PDB ID | 3C59 3C5T |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |