A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20436 |
| Swiss-prot Accession number | P33032 (Sequence in FASTA format) |
| Description | Melanocortin receptor 5 (MC5-R) (MC-2). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed in the brain but not in the melanoma cells. |
| Post translational modification | N/A |
| Function | Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. |
| Protein Length | 325 Amino acids |
| Molecular weight | 36601 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8396929 2 PubMed abstract 8179577 3 PubMed abstract 7739752 4 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 9240466 7 PubMed abstract 11286624 |
| Hormone | N/A |
| Gene ID | 4161 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |