A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20381 |
| Swiss-prot Accession number | Q543D4 (Sequence in FASTA format) |
| Description | 0 day neonate lung cDNA, RIKEN full-length enriched library,clone:E030013E04 product:5-hydroxytryptamine (serotonin) receptor 2 A,full insert sequence (5-hydroxytryptamine (Serotonin) receptor 2A). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Membrane (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production (By similarity). |
| Protein Length | 471 Amino acids |
| Molecular weight | 52842 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 10349636 2 PubMed abstract 16141072 3 PubMed abstract 16141073 4 PubMed abstract 12466851 5 PubMed abstract 11217851 6 PubMed abstract 11042159 7 PubMed abstract 11076861 8 Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W.,Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T.,Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T.,Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S.,Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M.,Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y.,Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H.,Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M.,Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T.,Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 9 PubMed abstract 12477932 10 Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases. |
| Hormone | N/A |
| Gene ID | 15558 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |