A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20338 |
| Swiss-prot Accession number | P28335 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 2C receptor (5-HT-2C) (Serotonin receptor 2C) (5-HT2C) (5-HTR2C) (5HT-1C). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N-glycosylated. |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 458 Amino acids |
| Molecular weight | 51821 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1722404 2 PubMed abstract 7895773 3 PubMed abstract 8812491 4 PubMed abstract 9928237 5 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15772651 7 PubMed abstract 15489334 8 PubMed abstract 11150294 9 PubMed abstract 7557992 10 PubMed abstract 10206230 11 PubMed abstract 10581480 12 PubMed abstract 10391209 13 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 14 PubMed abstract 1722404 15 PubMed abstract 7895773 16 PubMed abstract 8812491 17 PubMed abstract 9928237 18 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. 19 PubMed abstract 15772651 20 PubMed abstract 15489334 21 PubMed abstract 11150294 22 PubMed abstract 7557992 23 PubMed abstract 10206230 24 PubMed abstract 10581480 25 PubMed abstract 10391209 26 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). |
| Hormone | Detail in HMRbase |
| Gene ID | 3358 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |