A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20335 |
| Swiss-prot Accession number | Q02152 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 2B receptor (5-HT-2B) (Serotonin receptor 2B) (5-HT-2F) (NP75 protein). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Intestine and heart, but also in brain and kidney. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 479 Amino acids |
| Molecular weight | 53625 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1426253 2 Choi D.S., Maroteaux L.; "Genomic sequence of the 5-HT2B receptor locus."; Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 11471062 4 PubMed abstract 16141072 5 PubMed abstract 15489334 |
| Hormone | N/A |
| Gene ID | 15559 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |