A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20334 |
| Swiss-prot Accession number | P41595 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 2B receptor (5-HT-2B) (Serotonin receptor 2B). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Detected in most peripheral organs. Only low expression levels were found in the brain. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 481 Amino acids |
| Molecular weight | 54298 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8143856 2 PubMed abstract 7926008 3 PubMed abstract 8078486 4 PubMed abstract 10722792 5 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15815621 7 PubMed abstract 15489334 8 PubMed abstract 11150294 9 PubMed abstract 8143856 10 PubMed abstract 7926008 11 PubMed abstract 8078486 12 PubMed abstract 10722792 13 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. 14 PubMed abstract 15815621 15 PubMed abstract 15489334 16 PubMed abstract 11150294 17 PubMed abstract 8143856 18 PubMed abstract 7926008 19 PubMed abstract 8078486 20 PubMed abstract 10722792 21 Puhl H.L. III, Ikeda S.R., Aronstam R.S.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. 22 PubMed abstract 15815621 23 PubMed abstract 15489334 24 PubMed abstract 11150294 |
| Hormone | N/A |
| Gene ID | 3357 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |