A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20307 |
| Swiss-prot Accession number | P28564 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 1B receptor (5-HT-1B) (Serotonin receptor 1B) (5-HT1B). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated (By similarity). Palmitoylated (By similarity). |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Protein Length | 386 Amino acids |
| Molecular weight | 43163 |
| Domain Name | 7tm_1 |
| References | 1 Hamblin M.W., McGuffin R.W., Metcalf M.A., Dorsa D.M., Merchant K.M.; "Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: structural andpharmacological comparison of the two cloned receptors."; Mol. Cell. Neurosci. 3:578-587(1992).
2 PubMed abstract 1836757 |
| Hormone | N/A |
| Gene ID | 25075 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |