A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20303 |
| Swiss-prot Accession number | P28222 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 1B receptor (5-HT-1B) (Serotonin receptor 1B) (5-HT1B) (5-HT-1D-beta) (Serotonin 1D beta receptor) (S12). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated. |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Protein Length | 390 Amino acids |
| Molecular weight | 43568 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1565658 2 PubMed abstract 1351684 3 PubMed abstract 1610347 4 PubMed abstract 1315531 5 PubMed abstract 1559993 6 PubMed abstract 1328844 7 PubMed abstract 1348246 8 Kitano T., Kobayakawa H., Saitou N.; "Silver project."; Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. 9 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 10 PubMed abstract 14574404 11 PubMed abstract 15489334 12 PubMed abstract 8218242 13 PubMed abstract 7802650 14 PubMed abstract 1565658 15 PubMed abstract 1351684 16 PubMed abstract 1610347 17 PubMed abstract 1315531 18 PubMed abstract 1559993 19 PubMed abstract 1328844 20 PubMed abstract 1348246 21 Kitano T., Kobayakawa H., Saitou N.; "Silver project."; Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. 22 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 23 PubMed abstract 14574404 24 PubMed abstract 15489334 25 PubMed abstract 8218242 26 PubMed abstract 7802650 |
| Hormone | N/A |
| Gene ID | 3351 |
| PDB ID | 2G1X |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |