A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20180 |
| Swiss-prot Accession number | Q13285 (Sequence in FASTA format) |
| Description | Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein)(Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO- NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. |
| Protein Length | 461 Amino acids |
| Molecular weight | 51636 |
| Domain Name | zf-C4 Hormone_recep |
| References | 1 Santa Barbara P., Desclozeaux M., Boizet B., Bonneaud N., Laudet V.,Poulat F., Berta P.; "Cloning and characterization of the human steroidogenic factor 1 (SF-1) cDNA."; Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 8806624 3 PubMed abstract 15489334 4 Yeh J.R., Chung B.C.; "Human SF1 genomic segment."; Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 11897684 6 PubMed abstract 15707893 7 PubMed abstract 15897460 8 PubMed abstract 10369247 9 PubMed abstract 11038323 10 PubMed abstract 11932325 |
| Hormone | N/A |
| Gene ID | 2516 |
| PDB ID | 1YOW 1ZDT |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |