| HMRbase accession number | 20179 |
| Swiss-prot Accession number | Q04752 (Sequence in FASTA format) |
| Description | Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein)(Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1). |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Adrenal, ovary, testis, placenta, adipocyte, and brain. |
| Post translational modification | May be regulated by phosphorylation and dephosphorylation. |
| Function | Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by FTZF1. The SFPQ-NONO-NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP- dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3 (By similarity). |
| Protein Length | 461 Amino acids |
| Molecular weight | 51613 |
| Domain Name | zf-C4 Hormone_recep |
| References | 1 PubMed abstract 8463279
2 PubMed abstract 1406703
|
| Hormone | N/A |
| Gene ID | 281948 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
A database of hormones and their receptors