A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20173 |
| Swiss-prot Accession number | P04278 (Sequence in FASTA format) |
| Description | Sex hormone-binding globulin precursor (SHBG) (Sex steroid-bindingprotein) (SBP) (Testis-specific androgen-binding protein) (ABP)(Testosterone-estrogen-binding globulin) (Testosterone-estradiol-binding globulin) (TeBG). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted protein (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity) |
| Developmental Stage | N/A |
| Similarity | Contains 2 laminin G-like domains. |
| Tissue Specificity | Isoforms 1 and 2 are present in liver and testis. |
| Post translational modification | N/A |
| Function | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. |
| Protein Length | 402 Amino acids |
| Molecular weight | 43779 |
| Domain Name | Laminin_G_1 Laminin_G_2 |
| References | 1 PubMed abstract 2587256 2 PubMed abstract 2608061 3 PubMed abstract 15489334 4 PubMed abstract 3569533 5 PubMed abstract 2956126 6 PubMed abstract 2956125 7 PubMed abstract 3702459 8 PubMed abstract 3542030 9 PubMed abstract 16335952 10 PubMed abstract 1400872 11 PubMed abstract 10675319 12 PubMed abstract 12065592 13 PubMed abstract 7714097 14 PubMed abstract 10391209 15 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). |
| Hormone | N/A |
| Gene ID | 6462 |
| PDB ID | 1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |