| HMRbase accession number | 20170 |
| Swiss-prot Accession number | Q9GLC7 (Sequence in FASTA format) |
| Description | Parathyroid hormone-related protein precursor (PTH-rP) (PTHrP)[Contains: Osteostatin]. |
| Source organism | Oryctolagus cuniculus (Rabbit) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;Oryctolagus. |
| Subcellular location | Cytoplasm (By similarity). Nucleus (By similarity). Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the parathyroid hormone family. |
| Tissue Specificity | N/A |
| Post translational modification | There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity). |
| Function | Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differenciation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Osteostatin is a potent inhibitor of osteoclastic bone resorption (By similarity). |
| Protein Length | 177 Amino acids |
| Molecular weight | 20005 |
| Domain Name | Parathyroid |
| References | 1 McCaughern-Carucci J.F., Mitnick M., Emanuel J.R., Dworetzky S.I.; "Cloning and expression of rabbit parathyroid hormone-relatedprotein."; Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
|
| Hormone | N/A |
| Gene ID | 100009357 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
A database of hormones and their receptors