A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20169 |
| Swiss-prot Accession number | P70555 (Sequence in FASTA format) |
| Description | Parathyroid hormone receptor precursor (PTH2 receptor). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Abundantly expressed in brain, arterial and cardiac endothelium. Found as well in sperm, in the head of the epididymis. Lower expression is found in vascular smooth muscle, exocrine pancreas, testis and placenta. |
| Post translational modification | N/A |
| Function | This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTHR2 may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTHR2 presence in neurons indicates that it may function as a neurotransmitter receptor. |
| Protein Length | 546 Amino acids |
| Molecular weight | 61804 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 8828488 |
| Hormone | N/A |
| Gene ID | 81753 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |