A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20162 |
| Swiss-prot Accession number | P28069 (Sequence in FASTA format) |
| Description | Pituitary-specific positive transcription factor 1 (Pit-1) (Growthhormone factor 1) (GHF-1). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the POU transcription factor family. Class- 1 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3'. |
| Protein Length | 291 Amino acids |
| Molecular weight | 32912 |
| Domain Name | Pou Homeobox |
| References | 1 PubMed abstract 1956794 2 PubMed abstract 1370379 3 Tatsumi K., Notomi T., Irie Y., Endo Y., Onogi S., Amino N., Miyai K.; "The structure and the chromosomal location of the human PIT1 gene."; Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 1487156 5 PubMed abstract 7721104 6 PubMed abstract 8346040 7 PubMed abstract 1472057 8 PubMed abstract 1509263 9 PubMed abstract 1509262 10 PubMed abstract 8768831 11 PubMed abstract 9485179 12 PubMed abstract 9626142 13 PubMed abstract 11297581 |
| Hormone | N/A |
| Gene ID | 5449 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |