A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20156 |
| Swiss-prot Accession number | Q14995 (Sequence in FASTA format) |
| Description | Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclearhormone receptor BD73). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Binds to the sequences 5'-AATGTAGGTCA-3' and 5'- ATAACTAGGTCA-3'. Acts as a potent competitive repressor of ROR alpha function (By similarity). |
| Protein Length | 579 Amino acids |
| Molecular weight | 64643 |
| Domain Name | zf-C4 Hormone_recep |
| References | 1 Kamizono A., Shuichiro K., Kohei U.; "Isolation of a novel member of the thyroid/steroid hormone receptorsuperfamily from human osteoblastic osteosarcoma HOS cell."; Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 7997240 3 PubMed abstract 15489334 4 PubMed abstract 11113208 |
| Hormone | N/A |
| Gene ID | 9975 |
| PDB ID | 2V0V 2V7C 3CQV |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |