A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20046 |
| Swiss-prot Accession number | P33244 (Sequence in FASTA format) |
| Description | Nuclear hormone receptor FTZ-F1 (FTZ-F1 alpha). |
| Source organism | Drosophila melanogaster (Fruit fly) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila. |
| Subcellular location | Nucleus |
| Developmental Stage | First appears in blastoderm embryos. It is absent in subsequent embryo stages, and then reappears in late embryogenesis to be found in larvae, pupae and adults. |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expression in the parasegmental primordia of the embryonic blastoderm. |
| Post translational modification | N/A |
| Function | Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'- YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand. |
| Protein Length | 1027 Amino acids |
| Molecular weight | 108418 |
| Domain Name | zf-C4 Hormone_recep |
| References | 1 PubMed abstract 1709303 2 PubMed abstract 8096644 3 PubMed abstract 10731132 4 PubMed abstract 12537572 5 PubMed abstract 12537569 6 PubMed abstract 8164672 7 PubMed abstract 1448096 8 PubMed abstract 9020363 9 PubMed abstract 9020364 |
| Hormone | N/A |
| Gene ID | 40045 |
| PDB ID | 2IZ2 |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |