A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20042 |
| Swiss-prot Accession number | O08580 (Sequence in FASTA format) |
| Description | Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1) (Fragment). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | Expressed in an organ specific manner through mid-to late embryonic development with persistent high-level expression in brown adipose tissue and intestinal mucosa. |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Most highly expressed in kidney, heart, and brown adipocytes. Also found in uterus, cervix and vagina. |
| Post translational modification | Phosphorylated (Probable). |
| Function | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. May function as a modulator of the estrogen signaling pathway in the uterus. |
| Protein Length | 462 Amino acids |
| Molecular weight | 49281 |
| Domain Name | zf-C4 Hormone_recep |
| References | 1 PubMed abstract 9271417 2 PubMed abstract 9460651 3 PubMed abstract 17242355 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |