| HMRbase accession number | 20036 |
| Swiss-prot Accession number | Q9UHX3 (Sequence in FASTA format) |
| Description | EGF-like module-containing mucin-like hormone receptor-like 2precursor (EGF-like module EMR2) (CD312 antigen). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 5 EGF-like domains. Contains 1 GPS domain. |
| Tissue Specificity | Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. |
| Post translational modification | Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit. |
| Function | Receptor probably involved in cell attachment. |
| Protein Length | 823 Amino acids |
| Molecular weight | 90472 |
| Domain Name | EGF_CA 7tm_2 GPS EGF |
| References | 1 PubMed abstract 10903844
2 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
3 PubMed abstract 15057824
4 PubMed abstract 12860403
5 PubMed abstract 12829604
6 PubMed abstract 11994511
|
| Hormone | N/A |
| Gene ID | 30817 |
| PDB ID | 2BO2 2BOU 2BOX |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
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