A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11575 |
| Swiss-prot Accession number | P00797 (Sequence in FASTA format) |
| Description | Renin; EC=3.4.23.15;Alternative Name: Angiotensinogenase;Precursor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2 |
| Developmental Stage | N/A |
| Similarity | Belongs to the peptidase A1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Protein Length | 406 Amino acids |
| Molecular weight | 45057 |
| References | 1 PubMed abstract 6324167 2 PubMed abstract 3530608 3 PubMed abstract 6391881 4 PubMed abstract 16710414 5 PubMed abstract 15489334 6 PubMed abstract 6138751 7 PubMed abstract 3032746 8 PubMed abstract 2540188 9 PubMed abstract 3516796 10 PubMed abstract 2016271 11 PubMed abstract 12045255 12 PubMed abstract 2493678 13 PubMed abstract 1608447 14 PubMed abstract 16116425 |
| Domain Name | A1_Propeptide Asp |
| Hormone Name | Renin |
| Mature Hormone Sequence | |
| Position of mature hormone in Pre-Hormone protein | |
| Receptor | O75787 Detail in HMRbase |
| Gene ID | 5972 |
| PDB ID | 1BBS 1BIL 1BIM 1HRN 1RNE 2BKS 2BKT 2FS4 2G1N 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 2I4Q 2IKO 2IKU 2IL2 2REN 2V0Z 2V10 2V11 2V12 2V13 2V16 3D91 |
| Drugpedia | wiki |
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