A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11522 |
| Swiss-prot Accession number | P50595 (Sequence in FASTA format) |
| Description | Leptin;Alternative Name: Obesity factor; Precursor |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Secreted (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the leptin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
| Protein Length | 167 Amino acids |
| Molecular weight | 18716 |
| References | 1 PubMed abstract 10594237 2 PubMed abstract 14629116 3 PubMed abstract 16305752 4 PubMed abstract 8661738 |
| Domain Name | Leptin |
| Hormone Name | Leptin |
| Mature Hormone Sequence | |
| Position of mature hormone in Pre-Hormone protein | |
| Receptor | Q32PD8 Detail in HMRbase Q3SYT0 Detail in HMRbase Q59HQ0 Detail in HMRbase Q5KQU4 Detail in HMRbase Q5KQU5 Detail in HMRbase |
| Gene ID | 280836 |
| PDB ID | 2A16 |
| Drugpedia | wiki |
| Comments |