A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11448
Swiss-prot Accession numberP41520 (Sequence in FASTA format)
DescriptionCholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityN/A
Post translational modification The precursor cleaved by enzymes to produce a number of active cholecystokinins.
FunctionThis peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Protein Length115 Amino acids
Molecular weight12835
References1   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
2  PubMed abstract 2217909
3  PubMed abstract 4011954
Domain NameGastrin  
Hormone NameCholecystokinin-39
Mature Hormone SequenceYIQQARKAPSGRMSVIKNLQSLDPSHRISDRDYMGWMDF
Position of mature hormone in Pre-Hormone protein39 Residues from position (65-103)
ReceptorP79266    Detail in HMRbase   
Gene ID617510      
PDB IDN/A
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