A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11429 |
| Swiss-prot Accession number | P24393 (Sequence in FASTA format) |
| Description | Gastrin-releasing peptide precursor (GRP) [Contains: Neuromedin-C(GRP-10)]. |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted |
| Developmental Stage | N/A |
| Similarity | Belongs to the bombesin/neuromedin-B/ranatensin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear |
| Protein Length | 147 Amino acids |
| Molecular weight | 15817 |
| References | 1 PubMed abstract 2843761 |
| Domain Name | Bombesin |
| Hormone Name | Gastrin-releasing peptide |
| Mature Hormone Sequence | APVSTGAGGGTVLAKMYPRGSHWAVGHLM |
| Position of mature hormone in Pre-Hormone protein | 29 Residues from position (24-52) |
| Receptor | P52500
Detail in HMRbase |
| Gene ID | 171101 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |