A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11294
Swiss-prot Accession numberP01201 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide;Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha(Alpha-MSH); Corticotropin-like intermediary peptide (CLIP);Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropinbeta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organismMacaca nemestrina (Pig-tailed macaque)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Stimulates melanocytes to produce melanin. It performs lipid-mobilizing functions such as lipolysis and steroidogenesis.
Protein Length264 Amino acids
Molecular weight29172
References1  PubMed abstract 3229286
2  PubMed abstract 13760276
3  PubMed abstract 3229286
4  PubMed abstract 13760276
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameLipotropin beta (Beta-LPH)
Mature Hormone SequenceELTGQRPRAGDGPDGPADDGAGPRADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGQ
Position of mature hormone in Pre-Hormone protein89 Residues from position (176-264)
ReceptorQ864J8    Detail in HMRbase   
Gene IDN/A
PDB IDN/A
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