A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11280
Swiss-prot Accession numberP01192 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismSus scrofa (Pig)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Beta-endorphin is an endogenous opiate
Protein Length267 Amino acids
Molecular weight28895
References1  PubMed abstract 3753882
2  PubMed abstract 6196724
3  PubMed abstract 7958386
4  PubMed abstract 6547437
5   Shepherd R.G., Willson S.D., Howard K.S., Bell P.H., Davies D.S.,Davis S.B., Eigner E.A., Shakespeare N.E.; "Studies with corticotropin. III. Determination of the structure ofbeta-corticotropin and its active degradation products."; J. Am. Chem. Soc. 78:5067-5076(1956).
6  PubMed abstract 4334191
7  PubMed abstract 4369114
8  PubMed abstract 2174774
9  PubMed abstract 13451616
10  PubMed abstract 5543613
11   Gilardeau C., Chretien M.; "Complete amino acid sequence of porcine beta-lipotropic hormone(beta-LPH)."; (In) Meienhofer J. (eds.);Chemistry and biology of peptides, pp.609-611, Ann Arbor Sci. Pub.,Ann Arbor (1972).
12  PubMed abstract 4673865
13  PubMed abstract 13348631
14   Geschwind I.I., Li C.H., Barnafi L.; "The structure of the beta-melanocyte-stimulating hormone."; J. Am. Chem. Soc. 79:620-625(1957).
15  PubMed abstract 1207728
16  PubMed abstract 1007884
17  PubMed abstract 3753882
18  PubMed abstract 6196724
19  PubMed abstract 7958386
20  PubMed abstract 6547437
21   Shepherd R.G., Willson S.D., Howard K.S., Bell P.H., Davies D.S.,Davis S.B., Eigner E.A., Shakespeare N.E.; "Studies with corticotropin. III. Determination of the structure ofbeta-corticotropin and its active degradation products."; J. Am. Chem. Soc. 78:5067-5076(1956).
22  PubMed abstract 4334191
23  PubMed abstract 4369114
24  PubMed abstract 2174774
25  PubMed abstract 13451616
26  PubMed abstract 5543613
27   Gilardeau C., Chretien M.; "Complete amino acid sequence of porcine beta-lipotropic hormone(beta-LPH)."; (In) Meienhofer J. (eds.);Chemistry and biology of peptides, pp.609-611, Ann Arbor Sci. Pub.,Ann Arbor (1972).
28  PubMed abstract 4673865
29  PubMed abstract 13348631
30   Geschwind I.I., Li C.H., Barnafi L.; "The structure of the beta-melanocyte-stimulating hormone."; J. Am. Chem. Soc. 79:620-625(1957).
31  PubMed abstract 1207728
32  PubMed abstract 1007884
Domain NameACTH_domain  NPP  Op_neuropeptide  
Hormone NameBeta-endorphin
Mature Hormone SequenceYGGFMTSEKSQTPLVTLFKNAIVKNAHKKGQ
Position of mature hormone in Pre-Hormone protein31 Residues from position (237-267)
ReceptorQ9TU05    Detail in HMRbase   
Gene ID396863      
PDB IDN/A
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