A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11187
Swiss-prot Accession numberP01356 (Sequence in FASTA format)
DescriptionCholecystokinins precursor (CCK) [Contains: Cholecystokinin 58(CCK58); Cholecystokinin 39 (CCK39); Cholecystokinin 33 (CCK33);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organismSus scrofa (Pig)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificitySynthesized in both cerebral cortex and duodenal mucosa
Post translational modification The precursor is cleaved by enzymes to produce a number of active cholecystokinins. Brain contains CCK-octapeptide (CCK8) and several CCK-desoctapeptides; whereas pig gut contains intact CCK33, CCK39, and CCK58 as well as CCK-octapeptide and the CCK- desoctapeptides. Distribution differences are due to tissue- specific post-translational processing events.
Function This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Protein Length114 Amino acids
Molecular weight12526
References1  PubMed abstract 6205394
2   Mutt V., Jorpes J.E.; Submitted (AUG-1970) to the PIR data bank.
3  PubMed abstract 5410106
4  PubMed abstract 8443599
Domain NameGastrin  
Hormone NameCholecystokinin-12
Mature Hormone SequenceISDRDYMGWMDF
Position of mature hormone in Pre-Hormone protein12 Residues from position (91-102)
ReceptorN/A
Gene ID397468      
PDB IDN/A
Drugpediawiki
Comments!Receptor for this Hormone are either unknown or have not yet been curated