A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10979
Swiss-prot Accession numberQ9YGK2 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: Corticotropin (Adrenocorticotropic hormone) (ACTH);Melanotropin alpha (Alpha-MSH); Corticotropin-like intermediarypeptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH); Beta-endorphin; Met-enkephalin].
Source organismThunnus obesus (Bigeye tuna)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Scombroidei;Scombridae; Thunnus.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityN/A
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
FunctionN/A
Protein Length222 Amino acids
Molecular weight24970
References1   Amemiya Y., Takahashi A., Kawauchi H.; "Tuna proopiomelanocortin cDNA."; Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
2   Amemiya Y., Takahashi A., Kawauchi H.; "Tuna proopiomelanocortin cDNA."; Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Domain NameNPP  ACTH_domain  Op_neuropeptide  
Hormone NameLipotropin gamma (Gamma-LPH)
Mature Hormone SequenceELASELLAAAEEEEEKAQEVMAEEEEEQKQLLQEKKDGSYKMKHFRWSGPPAS
Position of mature hormone in Pre-Hormone protein53 Residues from position (136-188)
ReceptorN/A
Gene IDN/A
PDB IDN/A
Drugpediawiki
Comments!Receptor for this Hormone are either unknown or have not yet been curated